When trying to create 2D drawings of large assemblies, some Virtual Memory overflow issue might unexpectedly occur. In this case, you can reload the assembly using the Quick Load option.
Using this method, when you create a drawing, the think3 application does not load the whole assembly, but each part one at a time, discarding it after processing. Therefore, this method is definitely less memory consuming, though it might be a bit slower. Furthermore, if the said method avoids the use of Virtual Memory, the whole layout creation could even be faster.